Step 1: In mitotic cell division, the number of cells doubles after each division. Starting with one cell, the pattern of division is as follows:
- After 1 division: 2 cells
- After 2 divisions: 4 cells
- After 3 divisions: 8 cells
- After 4 divisions: 16 cells
Step 2: Since the question asks about the total number of cells that have lost the ability to divide after four mitotic divisions, we need to consider cells that are no longer in the active cell cycle. Typically, after reaching a certain stage in development, some cells may enter a phase like G0, where they stop dividing.
Step 3: Given this, the correct number of cells that have lost the ability to divide is 4, because the cells from the 5th and subsequent stages have entered G0.
Conclusion: After 4 divisions, 4 cells have lost the ability to divide.