Question

Adenoviruses are frequently used in gene delivery experiments. Their average genome size is 36,000 base pairs. Of their total DNA content, up to how much of the adenovirus genome can be replaced by foreign DNA?

• A. 5000 base pairs
• B. 15,000 base pairs
• C. 20,000 base pairs
• D. 30,000 base pairs

Hint:

Consider the capacity of adenoviral vectors for foreign DNA replacement in gene therapy.

Answer 1

The Correct Option is D

Adenoviruses are widely used as vectors in gene therapy due to their ability to accommodate large foreign DNA inserts. Up to 30,000 base pairs of the adenovirus genome can be replaced by foreign DNA without compromising the infectivity or effectiveness of the virus as a delivery vehicle.