Question

According to USP, the range of sparingly solubility required to dissolve 1 part of solute should be

• A. 1 - 10
• B. 10 - 30
• C. 30 - 100
• D. 100 - 1000

Hint:

Understanding solubility classification aids in selecting proper solvents and designing appropriate dosage forms.

Answer 1

The Correct Option is C

Solubility is classified based on the amount of solvent required to dissolve one part of solute, often expressed as parts of solvent per part of solute. According to the United States Pharmacopeia (USP), the solubility ranges are categorized as follows: - Very soluble: less than 1 part solvent required
- Freely soluble: 1 - 10 parts solvent
- Sparingly soluble: 30 - 100 parts solvent
- Slightly soluble: 100 - 1000 parts solvent
- Very slightly soluble: 1000 - 10,000 parts solvent
- Practically insoluble or insoluble: more than 10,000 parts solvent
Thus, the range for sparingly soluble substances corresponds to dissolving 1 part of solute in 30 to 100 parts of solvent. This classification is crucial for pharmaceutical formulation and drug delivery as it influences dissolution rate and bioavailability.