Question:

A male human is heterozygous for autosomal genes A and B and is also hemizygous for hemophilic gene h. What proportion of his sperms will be abh

Updated On: Apr 4, 2024
  • \(\frac{1}{32}\)

  • \(\frac{1}{16}\)

  • \(\frac{1}{4}\)

  • \(\frac{1}{8}\)

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The Correct Option is D

Solution and Explanation

Haemophilia is a recessive disorder linked to the X chromosome. In this context, males possess one X and one Y chromosome. According to the given information, a male is heterozygous for 'A' and 'B' genes but hemizygous for the haemophilic 'h' gene, resulting in the genotype AaBbXhY.The X-chromosome carries the 'h' gene, while the Y chromosome lacks this haemophilic gene because it is exclusively associated with the X chromosome. From this genotype (AaBbXhY), various gametes (sperm) can be produced, including abXh, abY, ABXh, ABY, AbXh, AbY, aBXh, and aBY. Among these possibilities, only one of the eight gametes carries the abXh combination.Therefore, the percentage of male gametes (sperm) carrying the abXh combination is 12.5%, as indicated by option A.
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Concepts Used:

Non-Mendelian Genetics

The term - non-mendelian inheritance refers to any pattern of heredity in which features do not separate according to Mendel's laws. These principles describe how features linked with single genes on chromosomes in the nucleus are passed down through generations.

Types of Non-Mendelian Inheritance

Codominance Inheritance

It is a form of incomplete dominance in which both alleles for the same feature are expressed in the heterozygote at the same time. For example, the MN blood types of humans.

Incomplete Dominance

In a heterozygote, the dominant allele does not always completely cover the phenotypic expression of the recessive gene, resulting in an intermediate phenotype which is referred to as "incomplete dominance”.