Let's map out the family relationships based on the given statements.
1. A is the brother of B. (A and B are siblings, A is male).
2. C is the father of A. (This means C is also the father of B).
3. E is the daughter of B. (B is the parent of E).
4. D is the brother of E. (This means D is also a child of B, and D is male).
So, D and E are children of B.
The question asks for the uncle of D. The uncle is the brother of one's parent.
D's parent is B.
We need to find the brother of B.
From statement 1, we know that A is the brother of B.
Therefore, A is the uncle of D.